Cascode power amplifier bias circuits suitable for operating across multiple power supply domains are provided. In certain embodiments, a power amplifier system includes a cascode power amplifier and a multi-domain bias circuit that generates at least a first cascode bias voltage for the cascode power amplifier. The multi-domain bias circuit includes a coarse regulator that generates a regulated voltage based on a power supply voltage that is operable with multiple voltage levels associated with different power supply domains, a bandgap reference circuit that is powered by the regulated voltage and outputs a bandgap reference voltage, a bias voltage generator that generates multiple selectable bias voltages based on the bandgap reference voltage, and a bias voltage selector that chooses the first cascode bias voltage from amongst the selectable bias voltages.