Systems and methods for classifying network traffic to use cellular network slices based on application parameters are described. In some embodiments, an Information Handling System (IHS) may include: a processor and a memory coupled to the processor, the memory having program instructions stored thereon that, upon execution, cause the IHS to: receive a plurality of packets originated by a single application; classify each of the plurality of packets into one of a plurality of network slices based upon network parameters of the application, where each of the network slices is associated with a weight, and for each given packet among the plurality of packets, add a weight to a header portion of the given packet, where the weight corresponds to the given packet's classification.