The disclosure provides a method and a device in a User Equipment (UE) and a base station for wireless communication. The UE receives a first signaling. Transmits K radio signals and a first bit block in K time-frequency resource groups. The first signaling is used for determining a first time-frequency resource group. The first time-frequency resource group is reserved to transmission of a first bit block; time-domain resources occupied by the first time-frequency resource group are overlapping with time-domain resources occupied by at least one of the K time-frequency resource groups, and any two of the K time-frequency resource groups are orthogonal in time domain; the first bit block is transmitted in only K1 time-frequency resource group(s) among the K time-frequency resource groups; the first signaling corresponds to a first type or a second type is used for determining the K1 time-frequency resource group(s) from the K time-frequency resource groups.