A cable clamping mechanism for a bicycle comprises a linkage member, a fixing screw, a nut and a linkage cable. The linkage member includes a first surface and a second surface. A through hole on the linkage member passes through the first surface and the second surface. The fixing screw is provided in the through hole and includes a cable hole passing through a radial direction of the fixing screw, where in the cable hole is on a side of the second surface. The nut joints a bottom end of the fixing screw. The linkage cable passes through the cable hole. The nut presses against the linkage cable so as to clamp the linkage cable in the cable hole. the fixing screw is rotatable within the through hole relative to the linkage member so that the linkage cable can also simultaneously rotate relative to the linkage member.