Invention Grant
- Patent Title: Anti-TNF/IFN scFv-Fc bispecific antibody and uses thereof
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Application No.: US17115163Application Date: 2020-12-08
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Publication No.: US11673948B2Publication Date: 2023-06-13
- Inventor: Dong-Il Kim , Hyun-Myoung Cha , Jin-Hyuk Lim
- Applicant: JP DUETBIO CO., LTD
- Applicant Address: KR Seoul
- Assignee: JP DUETBIO CO., LTD
- Current Assignee: JP DUETBIO CO., LTD
- Current Assignee Address: KR Seoul
- Agency: Sughrue Mion, PLLC
- Main IPC: C07K16/24
- IPC: C07K16/24

Abstract:
Disclosed is anti-TNF/IFN scFv-Fc bispecific antibody and a pharmaceutical composition for prevention or treatment of inflammatory bowel disease, the composition containing the antibody. The bispecific antibody has a structure in which an Fc fragment is conjugated to an scFv bispecific antibody. Thus, a purification process thereof may be easy. The bispecific antibody may effectively and simultaneously conjugate to TNF-α and IFN-γ which independently play an important role in inducing Crohn's disease. Thus, the bispecific antibody may exhibit excellent effects in the treatment of inflammatory bowel disease including Crohn's disease.
Public/Granted literature
- US20220177571A1 ANTI-TNF/IFN scFv-Fc BISPECIFIC ANTIBODY AND USES THEREOF Public/Granted day:2022-06-09
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