- Patent Title: Method of treating metastatic triple negative breast cancer with radiotherapy combined with phosphatidyl inositol-3 kinase delta/gamma inhibitors and anti-PD-1 antibodies
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Application No.: US16920933Application Date: 2020-07-06
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Publication No.: US11673965B2Publication Date: 2023-06-13
- Inventor: In-Ah Kim , Min-Guk Han , Bum-Sup Jang , Mi-Hyun Kang , Won-Ick Chang
- Applicant: Seoul National University R&DB Foundation
- Applicant Address: KR Seoul
- Assignee: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
- Current Assignee: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
- Current Assignee Address: KR Seoul
- Agency: Lex IP Meister, PLLC
- Priority: KR 20190180060 2019.12.31
- Main IPC: C07K16/30
- IPC: C07K16/30 ; A61P35/04 ; A61K45/06 ; A61K31/52 ; C07K16/28
Abstract:
The present invention provides a pharmaceutical composition and a treatment method to be combined with radiotherapy, for treatment of triple negative breast cancer. More specifically, the pharmaceutical composition comprises a PD-1 blockade and a PI3Kγ δ inhibitor, and it has excellent effects of inhibiting tumor and enhancing immunity by combining the PD-1 blockade and PI3Kγ δ inhibitor with radiotherapy, compared to single therapy of each therapeutic agent.
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