A tube lock includes a lock housing, a clamp cover, and a tube clamp. The lock housing has a tube compartment having an opening therein. In this regard, the clamp cover mates with the lock housing to provide a barrier over the opening of the tube compartment. The tube clamp has a tube entry along a major surface thereof. A first tube passageway extends from the tube entry into the housing, and a tube receiving channel is coupled to the first tube passageway. The tube clamp also comprises a clamping mechanism having a lever handle, and a tube pinch that is coupled to the lever handle. When the clamp cover is mated with the lock housing, the lever handle of the clamping mechanism is prevented from transitioning from the second position to the first position, thus locking the tube inserted into the tube clamp.