Methods, apparatus, systems and articles of manufacture are disclosed to configure heterogenous components in an accelerator. An example apparatus includes a graph compiler to identify a workload node in a workload and generate a selector for the workload node, and the selector to identify an input condition and an output condition of a compute building block, wherein the graph compiler is to, in response to obtaining the identified input condition and output condition from the selector, map the workload node to the compute building block.