Embodiments herein include detecting a transformation in a circuit layout before clock tree synthesis is performed, and in response, estimating a latency offset, relative to a global latency value, for a clock pin in a clock gate circuit. Moreover, the embodiments includes determining, based on the latency offset, a timing constraint for combinational logic configured to generate an enable signal for the clock gate circuit and adjusting the circuit layout based on the timing constraint to affect when the combinational logic generates the enable signal.