Apparatus, systems, and methods to generate an edge aware brush for navigation and segmentation of images via a user interface are disclosed. An example processor is to at least: construct a brush for segmentation of image data; provide an interactive representation of the brush with respect to the image data via a user interface, the interactive representation to be displayed and made available for interaction in each of a plurality of viewports provided for display of views of the image data in the user interface; enable update of the viewports based on manipulation of the representation; facilitate display of a preview of a segmentation of the image data corresponding to a location of the representation; and, when the segmentation is confirmed, facilitate generation of an output based on the segmentation.