The present disclosure provides an e-liquid bottle engageable with an electronic cigarette. The e-liquid bottle includes a main body (11), a cover (12), and a control switch (14); the cover (12) forms at least one liquid outlet (121); the control switch (14) is arranged in the cover (12). The electronic cigarette includes a cartridge (21) and a liquid injection device (23); the cartridge (21) forms a liquid reservoir (A), and one end of the cartridge (21) comprises an end wall (223) and a second operation portion (222) extending axially outwards from the end wall (223); the end wall (223) forms one liquid injection opening (2231), the second operation portion (222) corresponds to the control switch (14); the liquid injection device (23) is arranged on the end of the cartridge (21) and forms a liquid injection channel, and a first liquid inlet (2321) is formed in the liquid injection channel.