The sterilization mask with UVC reflective chamber includes a chamber with reflective liner, through which inhaled and exhaled air passes. The reflective chamber is also referred to as a sterilization chamber. Using a reflective chamber ensures each photon of UVC light has a long life, thus dissipating slowly. Increasing the life of the UVC photons decreases the quantity of photons that must be created. Thus, less power is required to achieve the sterilization. Sterilization is defined as a 6-log reduction (99.9999%) of various microbes including viruses, bacteria, and spores. The reflective chamber is made reflective using an UVC internal reflective surface. This surface is preferably formed from ePTFE, or other equivalently UVC reflective material.