Invention Grant
- Patent Title: Cell-based assay for determining activity in the retinoblastoma pathway
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Application No.: US17500230Application Date: 2021-10-13
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Publication No.: US11692195B2Publication Date: 2023-07-04
- Inventor: Tatyana Naryshkina
- Applicant: Medical Diagnostic Laboratories, Inc
- Applicant Address: US NJ Hamilton
- Assignee: Medical Diagnostics Laboratories, LLC
- Current Assignee: Medical Diagnostics Laboratories, LLC
- Current Assignee Address: US NJ Hamilton
- Agent Arnold Braun
- The original application number of the division: US16192993 2018.11.16
- Main IPC: C12N15/79
- IPC: C12N15/79 ; C12N9/02 ; G01N33/50 ; C12Q1/48 ; C12N9/12
Abstract:
Disclosed are methods of determining activity of CDK4 and CDK6 variants upon exposure to CDK inhibitors, methods for determining activity of a Rb variant, methods for determining the activity of a p16 variant in a cell, and methods for determining the sensitivity of a CDK4 variant or a CDK6 variant to p16 in a cell. Stable cell lines for determining activity of CDK4 variants, CDK6 variants, Rb variants, and p16 variants are also disclosed.
Information query
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