The present disclosure relates to a cargo protection method, device and system, and a non-transitory computer-readable storage medium, relating to the technical field of unmanned aerial vehicles. The method of the present disclosure includes: determining whether an unmanned aerial vehicle is in a falling state or not according to a current acceleration in a vertical direction of the unmanned aerial vehicle and a current vertical distance from the unmanned aerial vehicle to the ground; and opening at least one airbag in a cargo hold of the unmanned aerial vehicle in a case where the unmanned aerial vehicle is in the falling state to protect a cargo in the cargo hold.