Systems and methods for generating a three-dimensional (3D) model of a user's dental arch based on two-dimensional (2D) images of dental impressions include a model training system that provides a machine learning model using training image(s) of a dental impression of a respective dental arch and a 3D training model of the respective dental arch. A model generation system receives first image(s) of a first dental impression of a user's dental arch and second image(s), which may be of the first dental impression or a second dental impression of the dental arch. The model generation system generates a first and second 3D model of the dental arch by applying the first image(s) and second image(s) to the machine learning model.