A network node (300), a wireless device (304) and methods therein, for handling interference in a wireless network where a Listen-Before-Talk, LBT, scheme is employed to control transmissions. The network node (300) determines whether a first wireless device (302) is compatible with a second wireless device (304) at a serving network node (300) so that uplink signals transmitted (3:1A, 3:2A) from the wireless devices (302, 304) are spatially separable at the serving network node (300). An LBT-related message is then transmitted (3:4A) to the first wireless device (302), which message indicates that the wireless devices (302, 304) are compatible or incompatible at the serving network node (300). The second wireless device (304) is then able to detect (3:4A), i.e. overhear, the LBT-related message and use it as a basis for deciding (3:5) whether to perform a transmission or not. The second wireless device (304) can thus decide to transmit when the compatibility information indicates that the wireless devices (302, 304) are compatible, or refrain from transmission when the compatibility information indicates that the wireless devices (302, 304) are incompatible.