Invention Grant
- Patent Title: Quaternary ammonium salt compound, preparation method therefor and use thereof
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Application No.: US16969005Application Date: 2019-01-31
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Publication No.: US11697639B2Publication Date: 2023-07-11
- Inventor: Jin Liu , Bowen Ke , Wensheng Zhang , Jun Yang , Lei Tang
- Applicant: WEST CHINA HOSPITAL, SICHUAN UNIVERSITY
- Applicant Address: CN Sichuan
- Assignee: WEST CHINA HOSPITAL, SICHUAN UNIVERSITY
- Current Assignee: WEST CHINA HOSPITAL, SICHUAN UNIVERSITY
- Current Assignee Address: CN Sichuan
- Agency: NKL Law
- Agent Allen Xue
- Priority: CN 1810144661.X 2018.02.11
- International Application: PCT/CN2019/074275 2019.01.31
- International Announcement: WO2019/154287A 2019.08.15
- Date entered country: 2020-12-22
- Main IPC: C07D207/02
- IPC: C07D207/02 ; C07D211/60 ; C07C231/12 ; C07C237/04 ; C07D205/04 ; C07D207/16 ; C07D223/06 ; C07D225/02

Abstract:
A compound is shown in formula I and can be in the form of a pharmaceutically acceptable salt, or a stereoisomer, or a solvate, or a prodrug, or a metabolite. The compound takes effect rapidly and has a long-time local anesthetic effect following a single dose, with the sensory nerve blocking time being greater than the motor nerve blocking time, has both a long-acting local anesthetic effect and a selective local anesthetic effect, significantly reduces side effects of the compositions QX314 and QX314 and a quaternary ammonium salt compound with surfactant structural characteristics, and is safer. The compound of formula I of the present invention and a pharmaceutically acceptable salt thereof can be used for preparing drugs that have a long-time local anesthetic effect and a selective local anesthetic effect.
Public/Granted literature
- US20210107872A1 QUATERNARY AMMONIUM SALT COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF Public/Granted day:2021-04-15
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