Invention Grant
- Patent Title: Anti-annexin A2 monoclonal antibodies
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Application No.: US16848828Application Date: 2020-04-14
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Publication No.: US11697681B2Publication Date: 2023-07-11
- Inventor: Simeon Cua , Andre Boon Hwa Choo , Heng Liang Tan , Wey Jia Fong , Vanessa Mei Yee Ding , Leonard Wen Yan Leong
- Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
- Applicant Address: SG Singapore
- Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
- Current Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
- Current Assignee Address: SG Singapore
- Agency: Womble Bond Dickinson (US) LLP
- Priority: SG 201606178X 2016.07.26
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/18 ; A61K47/68 ; A61P35/00 ; G01N33/574 ; A61K31/282 ; A61K31/337 ; A61K31/5377 ; A61K38/17 ; C07K14/705 ; A61K39/00

Abstract:
The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GYSITSGYSWH; a VHCDR2 having the amino acid sequence YIHYSGSTKYNPSLKS and a VHCDR3 having the amino acid sequence GSNYGFDY; and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLYSNDQKNYLA, a VLCDR2 having the amino acid sequence WASIRES, and a VLCDR3 having the amino acid sequence QQYYIYPLT. The present invention also relates to an antigen-binding protein, or an antigen-binding fragment thereof, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence VYSITSGYSWH; a VHCDR2 having the amino acid sequence YIHYSGSTKYNPSLKS, and a VHCDR3 having the amino acid sequence GTDNAVDY; and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLYSSNQKNYLA, a VLCDR2 having the amino acid sequence WAS SRES, and a VLCDR3 having the amino acid sequence QQYYIYPLT. Compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof and kits comprising the antigen-binding protein, or antigen-binding fragment thereof are also provided.
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