Invention Grant
- Patent Title: Pharmaceutical compositions and methods of use for activation of human fibroblast and myofibroblast apoptosis
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Application No.: US16343309Application Date: 2017-10-30
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Publication No.: US11697813B2Publication Date: 2023-07-11
- Inventor: John Xu , Patrick Y. Lu , Jia Zhou , Qingfeng Li , Vera Simonenko
- Applicant: Sirnaomics, Inc. , Jia Zhou , Qingfeng Li
- Applicant Address: US MD Gaithersburg
- Assignee: Sirnaomics, Inc.,Sirnaomics Medicine Technology (Suzhou) Co, Ltd.
- Current Assignee: Sirnaomics, Inc.,Sirnaomics Medicine Technology (Suzhou) Co, Ltd.
- Current Assignee Address: US MD Germantown; CN Suzhou
- Agency: Edell, Shapiro & Finnan, LLC
- International Application: PCT/US2017/059072 2017.10.30
- International Announcement: WO2018/081726A 2018.05.03
- Date entered country: 2019-04-18
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; C12N15/113 ; A61K31/713 ; A61K47/34
Abstract:
The current invention provides a method of activating fibroblast and myofibroblast apoptosis in a tissue of a mammal, comprising administering to the tissue a therapeutically effective amount of a composition comprising an siRNA molecule that binds to an mRNA that codes for TGFB1 protein in a mammalian cell, an siRNA molecule that binds to an mRNA that codes for COX-2 protein in a mammalian cell, and a pharmaceutically acceptable carrier comprising a pharmaceutically acceptable histidine-lysine polymer. The invention also provides additional methods for using this composition.
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