Systems and methods for accelerating hypercalls for nested virtual machines. An example method may comprise executing, by a host computer system, a Level 0 hypervisor managing a Level 1 virtual machine (VM). The Level 0 hypervisor receives a first function component from a Level 2 hypervisor managing a Level 3 VM, where the first function component performs a first functionality associated with a hypercall issued by the Level 3 VM; stores the first function component in a memory space associated with the Level 0 hypervisor; detects the hypercall issued by the Level 3 VM; and responsive to detecting the hypercall, executes the first function component to modify a VM context for the Level 3 VM.