Methods and systems for actively and adaptively cancelling the noise and vibration generated by medical devices. A method includes receiving data from one or more sensors of a medical device. The method includes determining a signature signal for the medical device based at least on the data. The signature signal is a representation of one or more physical byproducts of the medical device, and one or more environmental conditions of a physical environment proximate to the medical device. The method incudes determining an inverted signal based on the signature signal, the inverted signal configured to mask the signature signal. The method includes generating a physical representation of the inverted signal by one or more electrical or electromechanical components of the medical device, and masking the signature signal with the inverted signal.