The invention relates to an electronic device, and more particularly, to systems, devices and methods of authenticating the electronic device using a challenge-response process that is based on a physically unclonable function (PUF). The electronic device comprises a PUF element, a processor and a communication interface. The PUF element generates an input signal based on at least one PUF that has unique physical features affected by manufacturing variability. A challenge-response database, comprising a plurality of challenges and a plurality of corresponding responses, is set forth by the processor based on the PUF-based input and further provided to a trusted entity. During the trusted transaction, the processor generates a response in response to a challenge sent by the trusted entity based on the PUF-based input, and thereby, the trusted entity authenticates the electronic device by comparing the response with the challenge-response database.