Disclosed is a method for synthesizing an antimicrobial base. The method comprises treating a Silver salt in a reaction mixture. The method further comprises adding one or more reactants to the reaction mixture in a pre-defined ratio. Further, the method comprises heating the reaction mixture at a first temperature between 45° C. to 90° C. for a first period of 5 to 8 hours. Furthermore, the method comprises stabilizing the conversion by adding a ligand and a stabilizing agent. Subsequently, the method comprises digesting the reaction mixture at a second temperature between 45° C. to 65° C. for a period of 2 to 4 hours to form an end product. Finally, the method comprises filtering the reaction mixture. The sub-micron particle forms a dispersion containing the colloidal silver particles (Ag0), thereby forming the antimicrobial base.