Invention Grant
- Patent Title: Methods for treating cancers by prodrugs of clofarabine
-
Application No.: US17241087Application Date: 2021-04-27
-
Publication No.: US11701377B2Publication Date: 2023-07-18
- Inventor: Laurence I. Wu
- Applicant: Laurence I. Wu
- Applicant Address: TW Tainan
- Assignee: Laurence I. Wu
- Current Assignee: Laurence I. Wu
- Current Assignee Address: TW Tainan
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A61K31/70 ; A61K31/7076 ; A61P35/02

Abstract:
A compound useful for treating leukemia or myelodysplastic syndrome, having the structure of formula (I):
or a pharmaceutically acceptable salt thereof, wherein R1 is H or —C(═O)—O—R3, and R2 is H or —C(═O)—O—R4, provided R1 and R2 are not both H; and R3 and R4 are each independently selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, arylalkyl, cycloalkyl, cycloheteroalkyl, and heteroalkyl. In an exemplary compound of formula (I), R1 is —C(═O)—O—CH2—CH3, and R2 is H.
or a pharmaceutically acceptable salt thereof, wherein R1 is H or —C(═O)—O—R3, and R2 is H or —C(═O)—O—R4, provided R1 and R2 are not both H; and R3 and R4 are each independently selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, arylalkyl, cycloalkyl, cycloheteroalkyl, and heteroalkyl. In an exemplary compound of formula (I), R1 is —C(═O)—O—CH2—CH3, and R2 is H.
Public/Granted literature
- US20210244755A1 METHODS FOR TREATING CANCERS BY PRODRUGS OF CLOFARABINE Public/Granted day:2021-08-12
Information query
IPC分类: