Invention Grant
- Patent Title: In vitro and in vivo intracellular delivery of siRNA via self-assembled nanopieces
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Application No.: US17041399Application Date: 2019-03-26
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Publication No.: US11701379B2Publication Date: 2023-07-18
- Inventor: Qian Chen , Yupeng Chen , Hongchuan Yu
- Applicant: Rhode Island Hospital
- Applicant Address: US RI Providence
- Assignee: Rhode Island Hospital
- Current Assignee: Rhode Island Hospital
- Current Assignee Address: US RI Providence
- Agency: Adler Pollock & Sheehan P.C.
- International Application: PCT/US2019/024155 2019.03.26
- International Announcement: WO2019/191151A 2019.10.03
- Date entered country: 2020-09-24
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; A61K31/713 ; A61K47/54 ; A61K47/69 ; A61P19/02 ; C12N15/113
Abstract:
The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.
Public/Granted literature
- US20210023117A1 IN VITRO AND IN VIVO INTRACELLULAR DELIVERY OF SIRNA VIA SELF-ASSEMBLED NANOPIECES Public/Granted day:2021-01-28
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