- Patent Title: Gene editing-based method of attenuating the beta-amyloid pathway
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Application No.: US17494457Application Date: 2021-10-05
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Publication No.: US11701436B2Publication Date: 2023-07-18
- Inventor: Subhojit Roy , Jichao Sun
- Applicant: Wisconsin Alumni Research Foundation
- Applicant Address: US WI Madison
- Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
- Current Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
- Current Assignee Address: US WI Madison
- Agency: Cantor Colburn LLP
- The original application number of the division: US16251970 2019.01.18
- Main IPC: A61P25/28
- IPC: A61P25/28 ; A61K48/00 ; A61K9/00 ; C12N15/90 ; C07K14/47 ; C12N9/22 ; C12N15/10
Abstract:
Described herein is a method for treating Alzheimer's disease (AD) by selective silencing of the amyloid precursor protein (APP) using Cas9 nuclease gene editing. Methods of making and using genetic constructs comprising a Cas9 nuclease and a sequence encoding guide RNA (gRNA) specific to APP capable of truncating the C-terminus of APP, as well as compositions comprising these constructs, are provided.
Public/Granted literature
- US20220023444A1 Gene Editing-Based Method of Attenuating the Beta-Amyloid Pathway Public/Granted day:2022-01-27
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