Invention Grant
- Patent Title: Systemic delivery of polypeptides
-
Application No.: US16612648Application Date: 2018-05-14
-
Publication No.: US11701437B2Publication Date: 2023-07-18
- Inventor: Denitsa M. Milanova , George M. Church , Noah Davidsohn , Carl Schoellhammer , Robert S. Langer , Anna I. Mandinova , Carlo Giovanni Traverso
- Applicant: President and Fellows of Harvard College , Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc. , The General Hospital Corporation
- Applicant Address: US MA Cambridge
- Assignee: President and Fellows of Harvard College,Massachusetts Institute of Technology,The Brigham and Women's Hospital, Inc.,The General Hospital Corporation
- Current Assignee: President and Fellows of Harvard College,Massachusetts Institute of Technology,The Brigham and Women's Hospital, Inc.,The General Hospital Corporation
- Current Assignee Address: US MA Cambridge; US MA Cambridge; US MA Boston; US MA Boston
- Agency: Banner & Witcoff, Ltd.
- International Application: PCT/US2018/032600 2018.05.14
- International Announcement: WO2018/209359A 2018.11.15
- Date entered country: 2019-11-11
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K47/69 ; A61N7/00 ; C12N15/86 ; A61K9/70
Abstract:
A method for the systemic delivery of a polypeptide within a subject is provided by creating genetically modified skin cells via topical introduction of a genetically engineered virus which delivers a nucleic acid encoding a therapeutic polypeptide for expression by the skin cells, wherein the expressed therapeutic polypeptide is secreted by the skin cells and is introduced into the circulatory system of the subject.
Information query
