Invention Grant
- Patent Title: DAZA chelators as ligands in liver imaging
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Application No.: US16771696Application Date: 2018-12-10
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Publication No.: US11701439B2Publication Date: 2023-07-18
- Inventor: Martin Freesmeyer , Julia Greiser
- Applicant: X-NUCLEAR DIAGNOSTICS GMBH
- Applicant Address: DE Erfurt
- Assignee: X-NUCLEAR DIAGNOSTICS GMBH
- Current Assignee: X-NUCLEAR DIAGNOSTICS GMBH
- Current Assignee Address: DE Erfurt
- Agency: JMB Davis Ben-David
- Priority: DE 2017129405.8 2017.12.11
- International Application: PCT/EP2018/084107 2018.12.10
- International Announcement: WO2019/115429A 2019.06.20
- Date entered country: 2020-06-11
- Main IPC: A61K51/04
- IPC: A61K51/04 ; C07D243/08

Abstract:
The invention relates to compounds according to the general formula (I) or a pharmaceutically acceptable salt of an inorganic or organic acid, a hydrate, a stereoisomer or a solvate thereof, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 being selected independently of one another from hydrogen and alkoxy. The compounds of formula (I) as ligands are suitable for the production of radioactively labelled 68Ga, 64Cu, 67Ga, 111In or 99mTc complexes. The invention further relates to a method for producing the compounds of formula (I) and the radioactively labelled complexes and to the use of the radioactively labelled complexes in imaging methods, such as PET/CT, in particular of the liver.
Public/Granted literature
- US20210069357A1 NEW DAZA CHELATORS AS LIGANDS IN LIVER IMAGING Public/Granted day:2021-03-11
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