Invention Grant
- Patent Title: Vitro characterization of cell injury due to mechanical blunt
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Application No.: US16999174Application Date: 2020-08-21
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Publication No.: US11702622B2Publication Date: 2023-07-18
- Inventor: Marc P. Raphael , Wonmo Kang
- Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
- Applicant Address: US VA Arlington
- Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
- Current Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
- Current Assignee Address: US DC Washington
- Agency: US Naval Research Laboratory
- Agent Rebecca Forman
- Main IPC: C12M1/12
- IPC: C12M1/12 ; C12M3/00 ; C12N5/071 ; C12M1/00 ; C12M1/42 ; C12M1/32
Abstract:
A system and method for studying cell injury mechanisms by applying biologically relevant mechanical impact to in vitro cell culture are disclosed. This approach is for maintaining consistent in vitro conditions during experiments, accommodating multiple cell populations, and monitoring each in real-time while achieving amplitude and time scale of input acceleration that mimic blunt injury cases. These multiplexed, environmental control capabilities enable characterizing the relationships between mechanical impact and cell injury in multivariate biological systems.
Public/Granted literature
- US20210054325A1 VITRO CHARACTERIZATION OF CELL INJURY DUE TO MECHANICAL BLUNT Public/Granted day:2021-02-25
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