Invention Grant
- Patent Title: TRNA/pre-miRNA compositions and methods for treating hepatocellular carcinoma
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Application No.: US17048466Application Date: 2019-04-19
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Publication No.: US11702657B2Publication Date: 2023-07-18
- Inventor: Aiming Yu , Joseph L Jilek , Qianyu Zhang , Pui Yan Ho , Meijuan Tu
- Applicant: The Regents of the University of California
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Bozicevic, Field & Francis LLP
- Agent Brian E. Davy
- International Application: PCT/US2019/028331 2019.04.19
- International Announcement: WO2019/204733A 2019.10.24
- Date entered country: 2020-10-16
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61P35/00 ; C12N15/115
Abstract:
Provided are hybrid tRNA/pre-microRNA and tRNA molecules and their use in methods of preventing and treating hepatocellular carcinoma (HCC). In some embodiments, provided are polynucleotides that include a tRNA operably linked to one or more pre-microRNA (pre-miRNA), where the tRNA and/or pre-miRNA are operably linked to one or more inserted RNA molecules that inhibit the growth or proliferation of a hepatocellular carcinoma (HCC) cell.
Public/Granted literature
- US20210087564A1 tRNA/pre-miRNA Compositions and Methods For Treating Hepatocellular Carcinoma Public/Granted day:2021-03-25
Information query
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