A bio-hybrid odor-localizing autonomous air vehicle includes an airborne robotic platform having a navigation platform, a wireless transmitter communicatively coupled to a management console, and a biological sensor mounted on the airborne robotic platform that reacts to at least one olfactory odor. A controller is communicatively coupled to the airborne robotic platform, the navigation platform, and the biological sensor. The controller monitors the biological sensor. In response to the biological sensor detecting the at least one olfactory odor, the controller directs the airborne platform to three-dimensionally map an olfactory plume of the at least one olfactory odor using an olfactory-driven search pattern. The controller stores the three-dimensional map for later retrieval or transmits the three-dimensional map of the olfactory plume to the management console via the wireless transmitter.