A system includes a first memory device having a region allocated as a first persistent memory region (PMR) having a first set of pages, a second memory device comprising a non-volatile memory device having a region allocated as a second PMR region having a second set of pages, and at least one processing device, operatively coupled to the first memory device and the second memory device, to implement a PMR mechanism to cause the second PMR region to be accessible through the first PMR region.