A method of garment deformation based on Laplacian deformation of a human body, including the following steps: inputting polygonal mesh models of the human body and the garment; discretizing non-homogeneous mesh models of the human body and the garment inputted in the first step; clustering all the discretized mesh vertices, to reduce a number of vertices and to form a set of homogeneous discrete vertices; constructing Laplacian matrices of the human body and the garment; preprocessing and solving inverse matrices; editing by using the human body mesh as a control vertex, to drive a real-time smooth deformation of the garment mesh; and mapping a deformed and simplified mesh back to a mesh space of an original resolution to obtain deformed human body and garment mesh models.