Invention Grant
- Patent Title: RNA interference delivery formulation and methods for malignant tumors
-
Application No.: US16685283Application Date: 2019-11-15
-
Publication No.: US11708575B2Publication Date: 2023-07-25
- Inventor: Bharat Majeti , Jean-Pierre Clamme , Li Wang , Roger C. Adami , Wenbin Ying
- Applicant: Nitto Denko Corporation
- Applicant Address: JP Osaka
- Assignee: Nitto Denko Corporation
- Current Assignee: Nitto Denko Corporation
- Current Assignee Address: JP Osaka
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Main IPC: A61K47/00
- IPC: A61K47/00 ; A61K48/00 ; C12N15/113 ; A61P35/00 ; A61K31/712 ; A61K31/7125 ; A61K9/16 ; A61K47/24 ; A61K9/14 ; A61K9/19 ; A61K47/28
Abstract:
This invention provides formulations for use in distributing RNAi molecules targeted to a human GST-π for treating a malignant tumor in a subject. The formulation can include nanoparticles composed of an ionizable lipid, a DSPE lipid, and additional lipids. A drug product can be made by lyophilization of the formulation. This invention further provides methods for ameliorating or treating a malignant tumor by administering a therapeutically effective amount of a formulation containing the RNAi agents.
Public/Granted literature
- US20200157540A1 RNA INTERFERENCE DELIVERY FORMULATION AND METHODS FOR MALIGNANT TUMORS Public/Granted day:2020-05-21
Information query
