An endoscopy system that includes a computer system with a high definition display monitor and a handheld portion. The handheld portion includes a re-usable handle portion and a single use portion that is configured to be disposed of following a single use. The single-use portion includes an elongated cannula with an imaging module and illumination modules at its distal tip. The handheld portion includes multiple sensors that can detect and measure rotation of the cannula relative to the handle portion, and rotation of the entire handheld portion. The sensor data is used to correctly orient and display images captured by the imaging module onto the high definition display monitor.