The present disclosure pertains to a system and method for facilitating pressure support therapy, mechanical inexsufflation therapy, and suctioning therapy for a subject. The system and method described herein offer a novel combination of mechanical inexsufflation with suctioning from a vacuum system. The invasive nature of current closed suctioning systems poses many potential risks, such as tissue trauma, less optimum secretion clearance at the peripheral airway, and lung decruitment. The system and method described herein provide a non-invasive method of suctioning with a suctioning volume measurement and a monitoring alarm to ensure a baseline lung volume and a positive end expiratory pressure (PEEP) level are maintained. This non-invasive method of suctioning is provided together with mechanical inexsufflation and pressure support therapy.