A method and apparatus for treatment of cancer is provided. The method can include systemic delivery of A3 selective adenosine receptor (A3AR) agonists CI-IB-MECA, cordycepin or similar drugs and providing simultaneous pulsed Electric Field (EF) stimulation to the treatment area. EF stimulation can be delivered in three orthogonal directions, which significantly increases expression of A3ARs on the cellular membranes and allows achieving a downstream apoptotic signal that is 4-6 fold stronger than the signal achieved with the agonist drugs alone.