A multi-well microtiter plate is provided designed for high-throughput screening of piercing-sucking arthropods,such as insects exposed to various compounds. The microtiter plates comprise a base comprising a plurality of sample wells, a covering made from pierceable material, a housing unit comprising a plurality of housing wells providing a predetermined fit in the plurality of sample wells, and an air-penetrable seal. Methods for containing, screening, and/or imaging piercing-sucking pests andarthropods utilizing the multi-chambered microtiter plates are also provided.