Various embodiments of a tire having a three-dimensional tire sipe are disclosed. In one embodiment, a tire sipe used in a tire is provided, the tire sipe comprising: a radially inner sipe taper portion having a radially inner sipe width W3 and a radially inner sipe transition width W4, wherein the radially inner sipe width W3 is greater than the radially inner sipe transition width W4; a radially outer sipe taper portion having a radially outer sipe width W1 and a radially outer sipe transition width W2, wherein the radially outer sipe width W1 is greater than the radially outer sipe transition width W2; and a sipe radially central portion having a plurality of individual sipe radially angled portions oriented in a zig-zag pattern, wherein the sipe radially central portion is oriented radially between the radially inner sipe taper portion and the radially outer sipe taper portion.