A vehicle interior panel includes a thermoelectric air conditioner capable of providing conditioned air locally within a passenger cabin of the vehicle. Air is drawn from the passenger cabin through an intake port in the panel, conditioned locally along a back side of the panel by a thermoelectric device, and discharged back into the cabin through a discharge port in the panel. Additional air flows along a waste side of the thermoelectric device and can be discharged outside the passenger cabin. The panel can be an interior door panel from which the waste side air is discharged within a B-pillar of the vehicle body.