An inline packaging machine for automatically accommodating and filling different sized containers, such as pouches, to reduce changeover time and thereby improve operating efficiency of the machine. The machine includes stations disposed longitudinally along a center line of the machine, including a first carrier track opposing a second carrier track with respect to the center line. A first clamp is disposed on the first carrier track and at least a second clamp is disposed on the second carrier track wherein the clamps are configured to releasably secure first-sized pouches for filling. The pouches are advanced inline from a setup station through an opening station to a filling station for filling with contents. The filled pouches are then advanced to a sealing and discharging station. A control system automatically adjusts the distance between the corresponding clamps to accommodate second-sized and/or third-sized pouches for inline processing and filling.