Self-cleaning electrochemical cells, systems including self-cleaning electrochemical cells, and methods of operating self-cleaning electrochemical cells are disclosed. The self-cleaning electrochemical cell can include a plurality of concentric electrodes disposed in a housing, for example, a cathode and an anode, a fluid channel defined between the concentric electrodes, a separator residing between the concentric electrodes, first and second end caps coupled to respective ends of the housing, and an inlet cone. The separators may be configured to localize the electrodes and dimensioned to minimize a zone of reduced velocity occurring downstream from the separator. The end caps and inlet cone may be dimensioned to maintain fully developed flow and minimize pressure drop across the electrochemical cell.