Invention Grant
- Patent Title: 2,4,5-trisubstituted 1,2,4-triazolones useful as inhibitors of DHODH
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Application No.: US17407951Application Date: 2021-08-20
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Publication No.: US11713304B2Publication Date: 2023-08-01
- Inventor: Stefan Nikolaus Gradl , Duy Nguyen , Knut Eis , Judith Günther , Timo Stellfeld , Andreas Janzer , Sven Christian , Thomas Müller , Sherif El Sheikh , David B. Sykes , Steven James Ferrara , Michael Kröber , Claudia Merz , Michael Niehues , Martina Schäfer , Katja Zimmermann , Carl Friedrich Nising
- Applicant: BAYER AKTIENGESELLSCHAFT , BAYER PHARMA AKTIENGESELLSCHAFT , THE BROAD INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE GENERAL HOSPITAL CORPORATION
- Applicant Address: DE MA Leverkusen
- Assignee: BAYER AKTIENGESELLSCHAFT,BAYER PHARMA AKTIENGESELLSCHAFT,THE BROAD INSTITUTE, INC.,PRESIDENT AND FELLOWS OF HARVARD COLLEGE,THE GENERAL HOSPITAL CORPORATION
- Current Assignee: BAYER AKTIENGESELLSCHAFT,BAYER PHARMA AKTIENGESELLSCHAFT,THE BROAD INSTITUTE, INC.,PRESIDENT AND FELLOWS OF HARVARD COLLEGE,THE GENERAL HOSPITAL CORPORATION
- Current Assignee Address: DE Leverkusen; DE Berlin; US MA Cambridge; US MA Cambridge; US MA Boston
- Agency: Greenberg Traurig, LLP
- Agent Melissa Hunter-Ensor; Scott Goncher
- Main IPC: A61P35/00
- IPC: A61P35/00 ; C07D401/12 ; C07D249/12 ; C07D403/12 ; C07D405/12 ; C07D413/12 ; A61K45/06
Abstract:
The present invention provides triazolone compounds of general formula (I):
in which R1, R2, R3, R4, and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and prophylaxis of diseases, in particular hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
in which R1, R2, R3, R4, and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and prophylaxis of diseases, in particular hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
Public/Granted literature
- US20220135536A1 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH Public/Granted day:2022-05-05
Information query
IPC分类:
| A | 人类生活必需 |
| A61 | 医学或兽医学；卫生学 |
| A61P | 化合物或药物制剂的特定治疗活性 |
| A61P35/00 | 抗肿瘤药 |
