Invention Grant
- Patent Title: Zinc sensors for in vivo imaging of beta-cell function by MRI
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Application No.: US16026340Application Date: 2018-07-03
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Publication No.: US11713305B2Publication Date: 2023-08-01
- Inventor: Andre F. Martins , Sara Chirayil , Maria Veronica Clavijo Jordan , A. Dean Sherry
- Applicant: The Board of Regents of the University of Texas System
- Applicant Address: US TX Austin
- Assignee: The Board of Regents of The University of Texas System
- Current Assignee: The Board of Regents of The University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Parker Highlander PLLC
- Main IPC: C07D401/14
- IPC: C07D401/14 ; A61K49/10 ; A61B5/00 ; C07F5/00 ; G01R33/56 ; A61B5/055
Abstract:
In some aspects, the present disclosure provides gadolinium based sensors which may be used to image zinc ions in vivo. In some embodiments, the compounds show appropriate reactivity with zinc ions while maintaining high relaxivity to achieve improved background relative to other sensors.
Public/Granted literature
- US20190031640A1 ZINC SENSORS FOR IN VIVO IMAGING OF BETA-CELL FUNCTION BY MRI Public/Granted day:2019-01-31
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