The present invention provides a fast chip removal reaming screw, including a screw head, a rod body extending from the screw head and a first thread arranged on the rod body. The rod body includes a rod body portion connected to the screw head, an reaming portion, and a pointed cone portion. The reaming portion includes first reaming blocks, second reaming blocks and third reaming blocks which are disposed in a helically staggered manner, and chip removal paths formed between the first reaming blocks, the second reaming blocks and the third reaming blocks. A first width of the chip removal path located between the first reaming blocks and a second width of the chip removal path located between the second reaming blocks are different, so that wood chips can be fast removed to reduce a stress between the screw and a wood workpiece.