A safety isolation valve module includes a conduit having a service port, an inlet, an outlet, and ball valves separating each of the inlet and the outlet from the conduit. The ball valves may be manually manipulating to open or close flow and can be used to isolate the service port from either or both sides of the refrigerant systems. When servicing the service port or other components of the refrigerant system, the valves may be shut to enable servicing of portions of the system without risking injury or losing significant amounts of refrigerant to the atmosphere.