The present application provides a display panel, a manufacturing method of the display panel, and a display device. The display panel includes a display region and a non-display region. The display panel includes multiple pixels divided by a boundary line. Each pixel has corresponding area uniformity. The pixels include multiple first pixels having the area uniformity within a first predetermined range. The pixels also include multiple second pixels having the area uniformity outside the first predetermined range. A shielding block is arranged on the first pixel. Brightness of the second pixel is set according to an area of the second pixel in the display region.