Provided are foldable electronic device and method for estimating bio-information by using the same. The foldable electronic device may include: a main body part including a first main body and a second main body that are configured to be folded toward each other or unfolded from each other along a fold line where the first main body and the second main body meet; an image sensor part including a first image sensor and a second image sensor which are disposed at the first main body; and a processor configured to obtain a contact image of an object from the first image sensor disposed at the first main body and obtain an image of a marker that is displayed on the second main body, from the second image sensor disposed at the first main body, when the object is in contact with the first image sensor and the main body part is folded along the fold line, and estimate bio-information based on the contact image of the object and the image of the marker.