Methods, systems, and computer-readable media are provided for facilitating mapping of semantically similar terms between and among two or more information systems. In particular, to facilitate automatic discovery, establishment, and/or statistical validation of linkages between a plurality of different nomenclatures employed by a plurality of information systems, such as multiple electronic health record systems. In embodiments, the imputation of latent synonymy in corpora comprised of samples of historical records from each system enables automated terminology mapping between disparate systems' records, thereby establishing reliable linkages that may subsequently be utilized for realtime decision support, data mining-based research, or other valuable purposes.