The present disclosure relates to the technical field of earphone and provides to an active noise reduction earphone. The active noise reduction earphone includes an earphone shell, a speaker, a sound outlet mouth, a first feedback digital microphone, a second feedback digital microphone and a sound collecting channel. Herein, the speaker divides the earphone shell into the front speaker cavity and the back speaker cavity; the sound outlet mouth is arranged to be faced to the speaker to output the sound emitted by the speaker; the first feedback digital microphone is arranged at the first noise reduction sound collecting hole preset in the back speaker cavity to collect external ambient noise; the sound in the ear canal is collected through the sound collecting channel, and the second feedback digital microphone isolates the sound collecting channel from the front speaker cavity.